From: Lipid recognition propensities of amino acids in membrane proteins from atomic resolution data
 | Propensity from crystal structuresa | Propensity from MD trajectories | Lipophilicity scaleb | |||||
---|---|---|---|---|---|---|---|---|
 | Head group | Tail group | Head group | Tail group | POPC | octanol | ||
TRP | 2.41 | (1.04) | 3.25 | (0.63) | 5.44 | 4.38 | -1.85 | -2.09 |
PHE | 1.55 | (0.50) | 1.96 | (0.43) | 0.97 | 1.97 | -1.13 | -1.71 |
TYR | 2.17 | (0.57) | 1.15 | (0.26) | 2.12 | 1.45 | -0.94 | -0.71 |
LEU | 0.75 | (0.17) | 1.60 | (0.23) | 0.80 | 1.70 | -0.56 | -1.25 |
ILE | 0.47 | (0.09) | 1.46 | (0.27) | 0.48 | 1.41 | -0.31 | -1.12 |
CYS | 0.47 | (0.32) | 1.16 | (0.93) | 0.06 | 1.68 | -0.24 | -0.02 |
MET | 0.96 | (0.25) | 1.47 | (0.38) | 1.01 | 1.56 | -0.23 | -0.67 |
GLY | 0.53 | (0.20) | 0.43 | (0.13) | 0.42 | 0.42 | 0.01 | 1.15 |
VAL | 0.60 | (0.18) | 1.24 | (0.41) | 0.40 | 1.23 | 0.07 | -0.46 |
SER | 0.68 | (0.20) | 0.89 | (0.25) | 0.73 | 0.44 | 0.13 | 0.46 |
THR | 0.82 | (0.25) | 0.76 | (0.15) | 0.43 | 0.35 | 0.14 | 0.25 |
ALA | 0.54 | (0.15) | 0.92 | (0.19) | 0.22 | 0.66 | 0.17 | 0.50 |
HIS | 1.99 | (0.39) | 0.53 | (0.09) | 1.35 | 0.88 | 0.17 | 0.11 |
ASN | 1.92 | (0.47) | 0.43 | (0.13) | 1.57 | 0.31 | 0.42 | 0.85 |
PRO | 0.56 | (0.37) | 0.35 | (0.12) | 0.77 | 0.65 | 0.45 | 0.14 |
GLN | 1.69 | (0.98) | 0.51 | (0.26) | 1.26 | 0.25 | 0.58 | 0.77 |
ARG | 2.42 | (0.65) | 0.27 | (0.21) | 3.85 | 0.43 | 0.81 | 1.81 |
LYS | 1.64 | (0.58) | 0.23 | (0.09) | 3.26 | 0.55 | 0.99 | 2.80 |
ASP | 0.51 | (0.32) | 0.06 | (0.04) | 0.61 | 0.00 | 1.23 | 3.64 |
GLU | 0.56 | (0.57) | 0.30 | (0.13) | 0.93 | 0.12 | 2.02 | 3.63 |