Fig. 15

Gradient in the cytosolic pSMAD2 and amount of the nuclear trimer concentration for the hepatocyte with extension. We observe a 16 % gradient (left) of cytosolic pSMAD2 in the modeled hepatocyte (solid line) and a 45 % gradient in the cell with extensions (dotted line). The amount of nuclear trimer concentration (right) in the steady state is lower for the cell with extensions, the molecules sojourn longer in the cytoplasm until they reach the nucleus