Skip to main content
Figure 1 | BMC Biophysics

Figure 1

From: Using default constraints of the spindle assembly checkpoint to estimate the associated chemical rates

Figure 1

A schematic view of the spindle assembly checkpoint and anaphase. A: Before all chromosomes are all attached, the mitotic checkpoint complex inhibits the Cdc20 molecules binding with APC/C to prevent premature separation of sister chromatids. This signal ubiquitylates Cdc20. B: When all chromosomes are properly attached, the inhibiting signal is shut down. C and D: Activation of APC/C triggers the separation of the chromatids and ultimately the anaphase.

Back to article page

BMC Biophysics

ISSN: 2046-1682

Contact us