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Figure 3 | BMC Biophysics

Figure 3

From: Molecular dynamics and mutational analysis of the catalytic and translocation cycle of RNA polymerase

Figure 3

The trigger loop hinges H1 (1230-GEPGTQ-1235) and H2 (1255-GLP-1257). Snapshots of the trigger loop region in open, closed and closed-Mg TECs are compared at about 10 ns simulation. Coloring is in “secondary structure” representation: helix is magenta, 310 helix is blue, coil is white, turn is cyan, β-sheet is yellow. G1230, P1232, H1242, G1255 and P1257 are in stick representation to locate the H1 and H2 hinges and orient the view. ATP and Mg are in space filling representation to locate the active site. Blue arrows indicate differences in secondary structure that develop during simulation.

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