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Figure 5 | BMC Biophysics

Figure 5

From: Molecular dynamics and mutational analysis of the catalytic and translocation cycle of RNA polymerase

Figure 5

Transcriptional activities of hinge H1 to H4 amino acid substitutions. A) Elongation and fidelity assays. Blue bars represent transcriptional elongation rate relative to wild type RNAP II at 200 μM NTP concentration. Error bars indicate standard error from exponential curve fitting. Red bars represent transcriptional fidelity, determined by a competition assay (Additional file 1: Figures S9 and S10). Error bars are standard deviation of at least three independent determinations. B) Conserved ionic interactions surrounding the Sc RNAP II H2 hinge.

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BMC Biophysics

ISSN: 2046-1682

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