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Table 2 Thermodynamic parameters of the protonation of inhibitor sulfonamide group and hCA XIII zinc-bound hydroxide anion at 25°C

From: Intrinsic thermodynamics of ethoxzolamide inhibitor binding to human carbonic anhydrase XIII

  Δ b_proton H, kJ/mol pK a K a , M Δ b_proton G, kJ/mol TΔ b_proton S, kJ/mol Δ b_proton S, J/(mol × K) Δ b_proton C p , J/(mol × K)
EZA −29.5 8.0 1.0 × 10-8 −45.7 16.2 54.2 88.7
TFMSA −23.9 6.25 5.6 × 10-7 −35.7 11.8 39.5 124.7
AZMa −23.0 7.30 5.0 × 10-8 −41.7 18.7 62.6 ND
CA-Zn-H2O −26.0 8.25 5.6 × 10-9 −47.1 21.1 70.7 ND
  1. Standard deviations are below 10% for all parameters measured in kJ/mol.
  2. a – data taken from [30].