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Table 2 Thermodynamic parameters of the protonation of inhibitor sulfonamide group and hCA XIII zinc-bound hydroxide anion at 25°C

From: Intrinsic thermodynamics of ethoxzolamide inhibitor binding to human carbonic anhydrase XIII

 

Δ b_proton H, kJ/mol

pK a

K a , M

Δ b_proton G, kJ/mol

TΔ b_proton S, kJ/mol

Δ b_proton S, J/(mol × K)

Δ b_proton C p , J/(mol × K)

EZA

−29.5

8.0

1.0 × 10-8

−45.7

16.2

54.2

88.7

TFMSA

−23.9

6.25

5.6 × 10-7

−35.7

11.8

39.5

124.7

AZMa

−23.0

7.30

5.0 × 10-8

−41.7

18.7

62.6

ND

CA-Zn-H2O

−26.0

8.25

5.6 × 10-9

−47.1

21.1

70.7

ND

  1. Standard deviations are below 10% for all parameters measured in kJ/mol.
  2. a – data taken from [30].