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Table 3 The intrinsic thermodynamic binding parameters of deprotonated inhibitor anion to the protonated form of zinc-bound water molecule of hCA XIII at 25°C

From: Intrinsic thermodynamics of ethoxzolamide inhibitor binding to human carbonic anhydrase XIII

 

Δ b H intr , kJ/mol

K b_intr , M-1

Δ b G intr , kJ/mol

TΔ b S intr , kJ/mol

Δ b S intr , J/(mol × K)

Δ b C p_intr , J/(mol × K)

EZA

−42.1

1.8 × 109

−52.8

10.7

35.9

−750

TFMSA

−33.5

4.6 × 107

−43.8

10.2

34.3

ND

AZM

−50.4

1.9 × 107

−41.5

−8.9

−29.8

ND