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Table 1 GPCR summary table

From: A minimal ligand binding pocket within a network of correlated mutations identified by multiple sequence and structural analysis of G protein coupled receptors

Receptor

PDB IDs [number of structures]

Ligands

Bovine Rhodopsin (BR)

1 F88, 1GZM, 1HZX, 1JFP, 1L9H, 1LN6, 1U19, 2 G87, 2HPY, 2I35, 2I36, 2I37, 2J4Y, 2PED, 3C9L, 3C9M, 3CAP, 3DQB [18]

RT, Ligand free

Squid Rhodopsin (SR)

2Z73, 2ZIY [2]

RT

Turkey β1 adrenergic receptor (β1AR)

2VT4, 2Y00, 2Y01, 2Y02, 2Y03, 2Y04 [6]

Cyanopindilol, Dobutamine Carmoterol, Isoprenaline Salbutamol

Human β2 adrenergic receptor (β2AR)

2R4R, 2R4S, 2RH1, 3D4S, 3KJ6, 3NY8, 3NY9, 3NYA, 3P0G, 3PDS [10]

Carazalol, Timolol, ICI 118,551, (molecule from Kolb et al., 2009), Alprenolol, BI-167107, FAUC50

Human A2A adenosine receptor (A2A)

3EML [1]

ZM241385

Human chemokine receptor (CXCR4)

3ODU, 3OE0, 3OE6, 3OE8, 3OE9 [5]

IT1t, CVX15

Human dopamine D3 receptor (D3R)

3PBL [1]

Eticlopride

  1. Summary of structural information available on GPCRs as of January 2011. While all ligands are small molecules, CVX15 (in bold) is a peptide.
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BMC Biophysics

ISSN: 2046-1682

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