A minimal ligand binding pocket within a network of correlated mutations identified by multiple sequence and structural analysis of G protein coupled receptors

Table 2 Comparison of edge distribution from control set and GREMLIN

Categories	Control set (Null Distribution)		GREMLIN (at penaltyλ = 38)		GREMLIN > Null	GREMLIN < Null
Categories	Total edges	% of edges	Total edges	% of edges	p value	p value
EC-EC	4095	6.78	169	23.80	0	1
EC-TM	14833	24.57	153	21.55	0.97	0.03
EC-IC	8554	14.17	56	7.89	1	0
TM-TM	13203	21.87	145	20.42	0.84	0.16
IC-TM	15322	25.38	81	11.41	1	0
IC-IC	4371	7.24	106	14.93	0	1
TOTAL	60378	100.00	710	100.00
EC-RT	2125	3.52	114	16.06	0	1
RT-TM	3600	5.96	98	13.80	0	1
IC-RT	2350	3.89	67	9.44	0	1
RT-RT	300	0.50	51	7.18	0	1
SUB-TOTAL	8375	13.87	330	46.48

ISSN: 2046-1682