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Table 2 Comparison of edge distribution from control set and GREMLIN

From: A minimal ligand binding pocket within a network of correlated mutations identified by multiple sequence and structural analysis of G protein coupled receptors

Categories Control set (Null Distribution) GREMLIN (at penaltyλ = 38) GREMLIN > Null GREMLIN < Null
Total edges % of edges Total edges % of edges p value p value
EC-EC 4095 6.78 169 23.80 0 1
EC-TM 14833 24.57 153 21.55 0.97 0.03
EC-IC 8554 14.17 56 7.89 1 0
TM-TM 13203 21.87 145 20.42 0.84 0.16
IC-TM 15322 25.38 81 11.41 1 0
IC-IC 4371 7.24 106 14.93 0 1
TOTAL 60378 100.00 710 100.00   
EC-RT 2125 3.52 114 16.06 0 1
RT-TM 3600 5.96 98 13.80 0 1
IC-RT 2350 3.89 67 9.44 0 1
RT-RT 300 0.50 51 7.18 0 1
SUB-TOTAL 8375 13.87 330 46.48