Skip to main content
Figure 1 | BMC Biophysics

Figure 1

From: Arbitrary protein−protein docking targets biologically relevant interfaces

Figure 1

Distribution of docking hits on the protein surface is not random. A: global distribution of hits generated by docking the 198 proteins in the target set with the 314 compact probes. B: global distribution of hits generated with a random model (see text). The insets illustrate the hit distributions on the surface of human HLA class 2 histocompatibility antigen (PDB code: 1 H15, chains A and B [41], the unbound form of 1KLU_r [42]). C: analysis of individual proteins. Cramer's test is used to compare the docking and random hit distributions for each protein. Grey: significant p-values, white: non-significant p-values. The significance level is set to 5% and p-values are adjusted using the Benjamini-Hochberg method.

Back to article page