Figure 2
From: Arbitrary protein−protein docking targets biologically relevant interfaces
Docking hits tend to accumulate near the center of proteins. A: global correlation between the relative distance to the geometric center of the protein, RGEOCEN, and the normalized number of docking hits, for exposed residues within the target set of 198 proteins, after docking with the 314 compact probes. The Pearson correlation coefficient and associated empirical p-value are shown on the graph. The regression line, y=1.16-0.29x, is shown in red. B: individual correlations for the 198 proteins of the target set. C: illustrative examples of proteins with zero, negative, and positive correlation. No correlation: 2HRA [43] (unbound form of protein 2HRK_r [44]). Negative correlation: 1IAM [45] (unbound form of protein 1MQ8_r [46]), docking hits concentrate near the geometric center. Positive correlation: 1 G16 [47] (unbound form of protein 3CPH_l [48]), docking hits concentrate on a protrusion, far from the center.