Figure 16

Representative conventional images of breast biopsies and structure-derived optical pathlength difference (OPD) map from a single cell nucleus (marked in circles) from (I) normal cells from a healthy patient; (II) cells labeled as fibrocystic changes from a non-proliferative benign patient; (III) cells labeled as ductal epithelial hyperplasia from a patient with concurrent apocrine metaplasia and cystic changes; (IV) cells labeled as atypical lobular hyperplasia; (V) cells as “normal” defined by the expert pathologist from a patient with invasive breast carcinoma (‘malignant-adjacent’ normal); and (VI) cells labeled as “malignant” from a patient with invasive breast carcinoma. The color bar represents the OPD value from the cell nucleus.