Fig. 6
From: α-synuclein-lanthanide metal ions interaction: binding sites, conformation and fibrillation
a Comparison of αS fibrillation rate in the presence of different metal ions. 100 μM αS in the presence of 0 μM metal ions (orange), 400 μM Ca2+ (gray), Mn2+ (violet), Cu2+ (magenta), Al3+ (blue), Dy3+ (cyan), Lu3+ (red), Tb3+ (green), respectively. Fluorescence intensity was normalized to 100 units. The error bars in figure were standard deviations of three measurements. Points with no visible error bars represent measurements with tiny variance. Solid lines were the fits according to equation 1. b Lag time t1/2 values (hours) obtained for αS in the absence and presence of different metal ions: control (89 ± 2), Ca2+ (82 ± 2), Mn2+ (75 ± 1), Cu2+ (17 ± 1), Al3+ (20 ± 1), Dy3+ (4 ± 1), Lu3+ (5 ± 1), Tb3+ (4 ± 1). Error bars denote the fitting errors of experiments