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Table 1 Kinetic model for gene expression with local supercoiling effects

From: A biophysical model of supercoiling dependent transcription predicts a structural aspect to gene regulation

Reaction

 

Propensity

(1)

DNA+RCoil→DNA+PCoil+mRNA

a o ×RCoil

(2)

mRNA→0

γ×mRNA

(3)

mRNA→Protein

b o ×γ×mRNA

(4)

Protein→0

d×Protein

(5)

Gyrase→Gyrase ′

K1

(6)

Gyrase ′→Gyrase

K2

(7)

Gyrase ′+PCoil→Gyrase ′+RCoil

R×PCoil