Modeling of RAS complexes supports roles in cancer for less studied partners

BMC Biophysics

Table 1 List of RAS isoform specific complex models generated via PRISM

PDB Chain for the RAS Protein	Gene Symbol of the RAS Protein	Interaction Partner	Gene Symbol of the Interactor Protein	Interface	Energy Score	Pfam Domain/Family of the Interactor
NRAS_model	NRAS	4g0nB	RAF1	1c1yAB	−52.35	RBD
NRAS_model	NRAS	4g0nB	RAF1	1c1yAB	−34.05	RBD
NRAS_model	NRAS	1g5mA	BCL2	1u8yAB	−23.32	BH4
4dsoA	KRAS	4g0nB	RAF1	1c1yAB	−46.71	RBD
4dsoA	KRAS	1c1yB	RAF1	1c1yAB	−45.94	RBD
4dsoA	KRAS	3kh0B	RALGDS	1lfdCD	−28.69	RALGDS/AF-6
4dsoA	KRAS	3ny5A	BRAF	1c1yAB	−26.42	RBD
4dsoA	KRAS	1zuzA	CALM	1qs7AC	−24.38	EF-hand-7
6q21A	HRAS	2lktA	RARRES3	3hbrAB	−38.81	Cytoplasmic Domain
6q21A	HRAS	4g0nB	RAF1	1c1yAB	−36.18	RBD
6q21A	HRAS	3kh0B	RALGDS	1lfdCD	−35.49	RALGDS/AF-6
6q21A	HRAS	1nf1A	NF1	1tx4AB	−28.38	RasGAP
6q21A	HRAS	3dadA	FHOD1	2ghpBD	−27.8	GBD/FH3
6q21A	HRAS	3w58C	LGALS1	2wfhAB	−26.46	Galectin
6q21A	HRAS	2h3lA	ERBB2IP	1w9aAB	−25.15	PDZ
6q21A	HRAS	2qbwA	ERBB2IP	3e9mAD	−23.61	PDZ
6q21A	HRAS	2c7nI	RABGEF1	2y3gAD	−23.53	zf-A20
6q21A	HRAS	1wxmA	ARAF	1c1yAB	−23.5	RBD
6q21A	HRAS	1g5mA	BCL2	1t35EF	−22.79	BH4
6q21A	HRAS	1yojA	SRC	1xdkEF	−21.72	Pkinase_Tyr

ISSN: 2046-1682