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Fig. 1 | BMC Biophysics

Fig. 1

From: GPMVs in variable physiological conditions: could they be used for therapy delivery?

Fig. 1

The effects of a hyper-osmotic solution on GPMVs. a The GPMVs were first kept in an isosmotic solution (300 mOsmoL/kg) and then b the solution was changed to a hyper-osmotic (500 mOsmoL/kg and c again to the initial one, where evaginations formed from some of them (see arrow). The GPMVs were imaged under an inverted microscope in bright-field with a water immersion objective (magnification 60X). d Time course of average GPMV volume change (n = 17). Between 0 and 5 min the vesicles were in the isosmotic solution (300 mOsmoL/kg), which was then gradually changed first to 400 mOsmoL/kg and after 5 min to 500 mOsmoL/kg. After 5 min the solutions were again gradually changed to decrease the osmotic value to 300 mOsmoL/kg at the end. The bar represents 10 μm

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