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  1. Intracellular transport is crucial for many cellular processes where a large fraction of the cargo is transferred by motor-proteins over a network of microtubules. Malfunctions in the transport mechanism under...

    Authors: Donatello Materassi, Subhrajit Roychowdhury, Thomas Hays and Murti Salapaka

    Citation: BMC Biophysics 2013 6:14

    Content type: Research article

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  2. Assembly of the ribosome from its protein and RNA constituents must occur quickly and efficiently in order to synthesize the proteins necessary for all cellular activity. Since the early 1960’s, certain charac...

    Authors: Brittany Burton Lott, Yongmei Wang and Takuya Nakazato

    Citation: BMC Biophysics 2013 6:13

    Content type: Research article

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  3. Keratins are important structural proteins found in skin, hair and nails. Keratin Intermediate Filaments are major components of corneocytes, nonviable horny cells of the Stratum Corneum, the outermost layer o...

    Authors: Anna Akinshina, Etienne Jambon-Puillet, Patrick B Warren and Massimo G Noro

    Citation: BMC Biophysics 2013 6:12

    Content type: Research article

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  4. Increasing applications of titanium dioxide (TiO2) fine particles (FPs) and nanoparticles (NPs) require coupled knowledge improvement concerning their biokinetic effects. Neutrophils are quickly recruited to tita...

    Authors: Everton Luis Santos da Rosa

    Citation: BMC Biophysics 2013 6:11

    Content type: Research article

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  5. PQS (Pseudomonas Quinolone Signal) and its precursor HHQ are signal molecules of the P. aeruginosa quorum sensing system. They explicate their role in mammalian pathogenicity by binding to the receptor PqsR that ...

    Authors: Anke Steinbach, Christine K Maurer, Elisabeth Weidel, Claudia Henn, Christian Brengel, Rolf W Hartmann and Matthias Negri

    Citation: BMC Biophysics 2013 6:10

    Content type: Research article

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  6. Water is essential for life, but some organisms can survive complete desiccation, while many more survive partial dehydration during drying or freezing. The function of some protective molecules, such as sugar...

    Authors: Antoaneta V Popova and Dirk K Hincha

    Citation: BMC Biophysics 2013 6:9

    Content type: Research article

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  7. Drop drying is a key factor in a wide range of technical applications, including spotted microarrays. The applied nL liquid volume provides specific reaction conditions for the immobilization of probe molecule...

    Authors: Jens Sobek, Catharine Aquino, Wilfried Weigel and Ralph Schlapbach

    Citation: BMC Biophysics 2013 6:8

    Content type: Research article

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  8. The human receptor tyrosine kinase MET and its ligand hepatocyte growth factor/scatter factor are essential during embryonic development and play an important role during cancer metastasis and tissue regenerat...

    Authors: Marina S Dietz, Daniel Haße, Davide M Ferraris, Antonia Göhler, Hartmut H Niemann and Mike Heilemann

    Citation: BMC Biophysics 2013 6:6

    Content type: Research article

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  9. Biomolecules or other complex macromolecules undergo conformational transitions upon exposure to an external perturbation such as ligand binding or mechanical force. To follow fluctuations in pairwise forces b...

    Authors: Bogdan I Costescu and Frauke Gräter

    Citation: BMC Biophysics 2013 6:5

    Content type: Methodology article

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  10. Transcription factories are nuclear domains where gene transcription takes placealthough the molecular basis for their formation and maintenance are unknown. In thisstudy, we explored how the properties of chr...

    Authors: Ana Z Canals-Hamann, Ricardo Pires das Neves, Joyce E Reittie, Carlos Iñiguez, Shamit Soneji, Tariq Enver, Veronica J Buckle and Francisco J Iborra

    Citation: BMC Biophysics 2013 6:2

    Content type: Research article

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  11. Regulating protein function in the cell by small molecules, provide a rapid, reversible and tunable tool of metabolic control. However, due to its complexity the issue is poorly studied so far. The effects of ...

    Authors: Rasha Bassam, Ilya Digel, Juergen Hescheler, Ayseguel Temiz Artmann and Gerhard M Artmann

    Citation: BMC Biophysics 2013 6:1

    Content type: Research article

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  12. Understanding the mechanical properties of chromatin is an essential step towards deciphering the physical rules of gene regulation. In the past ten years, many single molecule experiments have been carried ou...

    Authors: Jean Marc Victor, Jordanka Zlatanova, Maria Barbi and Julien Mozziconacci

    Citation: BMC Biophysics 2012 5:21

    Content type: Research article

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  13. Cholesterol is an important membrane component, but our knowledge about its transport in cells is sparse. Previous imaging studies using dehydroergosterol (DHE), an intrinsically fluorescent sterol from yeast,...

    Authors: Frederik W Lund, Michael A Lomholt, Lukasz M Solanko, Robert Bittman and Daniel Wüstner

    Citation: BMC Biophysics 2012 5:20

    Content type: Research article

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  14. Mollusc shells are commonly investigated using high-resolution imaging techniques based on cryo-fixation. Less detailed information is available regarding the light-optical properties. Sea shells of Haliotis pulc...

    Authors: Andreas S Schneider, Birgit Heiland, Nicolas J Peter, Christina Guth, Eduard Arzt and Ingrid M Weiss

    Citation: BMC Biophysics 2012 5:19

    Content type: Research article

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  15. Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically ac...

    Authors: Rasha Bassam, Juergen Hescheler, Ayseguel Temiz-Artmann, Gerhard M Artmann and Ilya Digel

    Citation: BMC Biophysics 2012 5:16

    Content type: Research article

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  16. EF-hand proteins can be activated by the binding of various heavy metals other than calcium, and such complexes can disturb the calcium-signaling pathway and cause toxicity and disease causing state. So far, n...

    Authors: Shivesh Kumar, Ejaz Ahmad, Sanjeev Kumar, Rizwan Hasan Khan and Samudrala Gourinath

    Citation: BMC Biophysics 2012 5:15

    Content type: Research article

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  17. G protein coupled receptors (GPCRs) are seven helical transmembrane proteins that function as signal transducers. They bind ligands in their extracellular and transmembrane regions and activate cognate G prote...

    Authors: Subhodeep Moitra, Kalyan C Tirupula, Judith Klein-Seetharaman and Christopher James Langmead

    Citation: BMC Biophysics 2012 5:13

    Content type: Research article

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  18. During elongation, multi-subunit RNA polymerases (RNAPs) cycle between phosphodiester bond formation and nucleic acid translocation. In the conformation associated with catalysis, the mobile “trigger loop” of ...

    Authors: Maria L Kireeva, Kristopher Opron, Steve A Seibold, Céline Domecq, Robert I Cukier, Benoit Coulombe, Mikhail Kashlev and Zachary F Burton

    Citation: BMC Biophysics 2012 5:11

    Content type: Research article

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  19. Gluten intolerance is a condition which affects an increasing percentage of the world’s population and for which the only current treatment is a restrictive gluten free diet. However could the inclusion of a p...

    Authors: M Samil Kök, Richard Gillis, Shirley Ang, David Lafond, Arthur S Tatham, Gary Adams and Stephen E Harding

    Citation: BMC Biophysics 2012 5:10

    Content type: Correspondence

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  20. Accurate modeling of electrostatic potential and corresponding energies becomes increasingly important for understanding properties of biological macromolecules and their complexes. However, this is not an eas...

    Authors: Lin Li, Chuan Li, Subhra Sarkar, Jie Zhang, Shawn Witham, Zhe Zhang, Lin Wang, Nicholas Smith, Marharyta Petukh and Emil Alexov

    Citation: BMC Biophysics 2012 5:9

    Content type: Software

    Published on:

  21. In the classical view, cell membrane proteins undergo isotropic random motion, that is a 2D Brownian diffusion that should result in an homogeneous distribution of concentration. It is, however, far from the r...

    Authors: Hédi A Soula, Antoine Coulon and Guillaume Beslon

    Citation: BMC Biophysics 2012 5:6

    Content type: Research article

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  22. The mechanism of action of volatile general anesthetics has not yet been resolved. In order to identify the effects of isoflurane on the membrane, we measured the steady-state anisotropy of two fluorescent pro...

    Authors: Steven C Nelson, Steven K Neeley, Eric D Melonakos, John D Bell and David D Busath

    Citation: BMC Biophysics 2012 5:5

    Content type: Research article

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  23. The V3 loop of the glycoprotein gp120 of HIV-1 plays an important role in viral entry into cells by utilizing as coreceptor CCR5 or CXCR4, and is implicated in the phenotypic tropisms of HIV viruses. It has be...

    Authors: Aliana López de Victoria, Chris A Kieslich, Apostolos K Rizos, Elias Krambovitis and Dimitrios Morikis

    Citation: BMC Biophysics 2012 5:3

    Content type: Research article

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  24. Protein-lipid interactions play essential roles in the conformational stability and biological functions of membrane proteins. However, few of the previous computational studies have taken into account the ato...

    Authors: Mizuki Morita, AVSK Mohan Katta, Shandar Ahmad, Takaharu Mori, Yuji Sugita and Kenji Mizuguchi

    Citation: BMC Biophysics 2011 4:21

    Content type: Research article

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  25. Along with high affinity binding of epibatidine (Kd1≈10 pM) to α4β2 nicotinic acetylcholine receptor (nAChR), low affinity binding of epibatidine (Kd2≈1-10 nM) to an independent binding site has been reported. St...

    Authors: Alexandra M Person and Gregg B Wells

    Citation: BMC Biophysics 2011 4:19

    Content type: Research article

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  26. We are exploring the viability of a novel approach to cardiocyte contractility assessment based on biomechanical properties of the cardiac cells, energy conservation principles, and information content measure...

    Authors: Carlos Bazan, Trevor Hawkins, David Torres-Barba, Peter Blomgren and Paul Paolini

    Citation: BMC Biophysics 2011 4:17

    Content type: Research article

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  27. The heat-shock response network controls the adaptation and survival of the cell against environmental stress. This network is highly conserved and is connected with many other signaling pathways. A key elemen...

    Authors: Jordan Cates, Garrett C Graham, Natalie Omattage, Elizabeth Pavesich, Ian Setliff, Jack Shaw, Caitlin Lee Smith and Ovidiu Lipan

    Citation: BMC Biophysics 2011 4:16

    Content type: Research article

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  28. Regulation of integrin binding to the specific complementary sites on extra-cellular matrix (ECM) proteins plays a major role in cell adhesion and migration. In addition to regulating single integrin-ligand bo...

    Authors: Erik S Welf, Ulhas P Naik and Babatunde A Ogunnaike

    Citation: BMC Biophysics 2011 4:15

    Content type: Research article

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  29. Fourier transform infrared spectroscopy (FTIR) has been used as analytical tool in chemistry for many years. In addition, FTIR can also be applied as a rapid and non-invasive method to detect and identify micr...

    Authors: Andrea Brandes Ammann and Helmut Brandl

    Citation: BMC Biophysics 2011 4:14

    Content type: Methodology article

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  30. Solutions containing high macromolecule concentrations are predicted to affect a number of protein properties compared to those properties in dilute solution. In cells, these macromolecular crowders have a lar...

    Authors: Andrew C Miklos, Conggang Li, Courtney D Sorrell, L Andrew Lyon and Gary J Pielak

    Citation: BMC Biophysics 2011 4:13

    Content type: Research article

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  31. Although biological membranes are organized as lipid bilayers, they contain a substantial fraction of lipids that have a strong tendency to adopt a nonlamellar, most often inverted hexagonal (HII) phase. The poly...

    Authors: Antoaneta V Popova and Dirk K Hincha

    Citation: BMC Biophysics 2011 4:11

    Content type: Research article

    Published on:

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