Figure 6

Double-ended zipper model of DNA hybridization. a) Duplex can only open and close from the ends in a zipper-like fashion. Between the two zipper fork positions k and l, the duplex is closed. $\mathrm{\Delta }{G}_{k,l}^o$ is the sum over all closed NN parameters in the bound duplex section. b) One MM affects two NN pairs.