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  1. Research

    Modeling of RAS complexes supports roles in cancer for less studied partners

    RAS protein interactions have predominantly been studied in the context of the RAF and PI3kinase oncogenic pathways. Structural modeling and X-ray crystallography have demonstrated that RAS isoforms bind to ca...

    H. Billur Engin, Daniel Carlin, Dexter Pratt and Hannah Carter

    BMC Biophysics 2017 10(Suppl 1):5

    Published on: 11 August 2017

    This article is part of a Supplement: Volume 10 Supplement 1

  2. Research article

    DNA secondary structure formation by DNA shuffling of the conserved domains of the Cry protein of Bacillus thuringiensis

    The Cry toxins, or δ-endotoxins, are a diverse group of proteins produced by Bacillus thuringiensis. While DNA secondary structures are biologically relevant, it is unknown if such structures are formed in region...

    Efrain H. Pinzon, Daniel A. Sierra, Miguel O. Suarez, Sergio Orduz and Alvaro M. Florez

    BMC Biophysics 2017 10:4

    Published on: 22 May 2017

  3. Software

    BFPTool: a software tool for analysis of Biomembrane Force Probe experiments

    The Biomembrane Force Probe is an approachable experimental technique commonly used for single-molecule force spectroscopy and experiments on biological interfaces. The technique operates in the range of force...

    Daniel Šmít, Coralie Fouquet, Mohamed Doulazmi, Frédéric Pincet, Alain Trembleau and Martin Zapotocky

    BMC Biophysics 2017 10:2

    Published on: 13 February 2017

  4. Research article

    Structure and domain dynamics of human lactoferrin in solution and the influence of Fe(III)-ion ligand binding

    Human lactoferrin is an iron-binding protein of the innate immune system consisting of two connected lobes, each with a binding site located in a cleft. The clefts in each lobe undergo a hinge movement from op...

    Clemens Sill, Ralf Biehl, Bernd Hoffmann, Aurel Radulescu, Marie-Sousai Appavou, Bela Farago, Rudolf Merkel and Dieter Richter

    BMC Biophysics 2016 9:7

    Published on: 4 November 2016

  5. Methodology article

    Rheological properties of cells measured by optical tweezers

    The viscoelastic properties of cells have been investigated by a variety of techniques. However, the experimental data reported in literature for viscoelastic moduli differ by up to three orders of magnitude. ...

    Yareni A. Ayala, Bruno Pontes, Diney S. Ether, Luis B. Pires, Glauber R. Araujo, Susana Frases, Luciana F. Romão, Marcos Farina, Vivaldo Moura-Neto, Nathan B. Viana and H. Moysés Nussenzveig

    BMC Biophysics 2016 9:5

    Published on: 22 June 2016

  6. Research Article

    Prediction of solution properties and dynamics of RNAs by means of Brownian dynamics simulation of coarse-grained models: Ribosomal 5S RNA and phenylalanine transfer RNA

    The possibility of validating biological macromolecules with locally disordered domains like RNA against solution properties is helpful to understand their function. In this work, we present a computational sc...

    Aarón Ayllón Benítez, José Ginés Hernández Cifre, Francisco Guillermo Díaz Baños and José García de la Torre

    BMC Biophysics 2015 8:11

    Published on: 1 December 2015

  7. Methodology article

    Copper-free click chemistry for attachment of biomolecules in magnetic tweezers

    Single-molecule techniques have proven to be an excellent approach for quantitatively studying DNA-protein interactions at the single-molecule level. In magnetic tweezers, a force is applied to a biopolymer th...

    Jorine M. Eeftens, Jaco van der Torre, Daniel R. Burnham and Cees Dekker

    BMC Biophysics 2015 8:9

    Published on: 25 September 2015

  8. Correspondence

    Life at the mesoscale: the self-organised cytoplasm and nucleoplasm

    The cell contains highly dynamic structures exploiting physical principles of self-organisation at the mesoscale (100 nm to 10 μm). Examples include non-membrane bound cytoplasmic bodies, cytoskeleton-based mo...

    Richard P Sear, Ignacio Pagonabarraga and Andrew Flaus

    BMC Biophysics 2015 8:4

    Published on: 25 February 2015

  9. Reviewer Acknowledgement

    BMC Biophysics reviewer acknowledgement 2014

    The editors of BMC Biophysics would like to thank all our reviewers who have contributed to the journal in Volume 7 (2014).

    Catherine J Potenski

    BMC Biophysics 2015 8:3

    Published on: 10 February 2015

  10. Research article

    Vesicle biomechanics in a time-varying magnetic field

    Cells exhibit distortion when exposed to a strong electric field, suggesting that the field imposes control over cellular biomechanics. Closed pure lipid bilayer membranes (vesicles) have been widely used for ...

    Hui Ye and Austen Curcuru

    BMC Biophysics 2015 8:2

    Published on: 21 January 2015

  11. Methodology article

    A novel delta current method for transport stoichiometry estimation

    The ion transport stoichiometry (q) of electrogenic transporters is an important determinant of their function. q can be determined by the reversal potential (Erev) if the transporter under study is the only elec...

    Xuesi M Shao, Liyo Kao and Ira Kurtz

    BMC Biophysics 2014 7:14

    Published on: 11 December 2014

  12. Research article

    Langevin dynamics simulations of charged model phosphatidylinositol lipids in the presence of diffusion barriers: toward an atomic level understanding of corralling of PIP2 by protein fences in biological membranes

    The polyvalent acidic lipid phosphatidylinositol, 4,5-bisphosphate (PIP2) is important for many cellular functions. It has been suggested that different pools of PIP2 exist in the cytoplasmic leaflet of the plasm...

    Kyu Il Lee, Wonpil Im and Richard W Pastor

    BMC Biophysics 2014 7:13

    Published on: 26 November 2014

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