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Research
RAS protein interactions have predominantly been studied in the context of the RAF and PI3kinase oncogenic pathways. Structural modeling and X-ray crystallography have demonstrated that RAS isoforms bind to ca...
BMC Biophysics 2017 10(Suppl 1):5
Published on: 11 August 2017
This article is part of a Supplement: Volume 10 Supplement 1
Research article
The Cry toxins, or δ-endotoxins, are a diverse group of proteins produced by Bacillus thuringiensis. While DNA secondary structures are biologically relevant, it is unknown if such structures are formed in region...
BMC Biophysics 2017 10:4
Published on: 22 May 2017
Research Article
Nanoparticles can be used as markers to track the position of biomolecules, such as single proteins, inside living cells. The activity of a protein can sometimes be inferred from changes in the mobility of the...
BMC Biophysics 2017 10:3
Published on: 23 March 2017
Software
The Biomembrane Force Probe is an approachable experimental technique commonly used for single-molecule force spectroscopy and experiments on biological interfaces. The technique operates in the range of force...
BMC Biophysics 2017 10:2
Published on: 13 February 2017
Methodology article
Single-molecule microscopic experiments can measure the mechanical response of proteins to pulling forces applied externally along different directions (inducing different residue pairs in the proteins by unia...
BMC Biophysics 2017 10:1
Published on: 31 January 2017
Research article
Human lactoferrin is an iron-binding protein of the innate immune system consisting of two connected lobes, each with a binding site located in a cleft. The clefts in each lobe undergo a hinge movement from op...
BMC Biophysics 2016 9:7
Published on: 4 November 2016
Research Article
The first step in many cellular signaling processes occurs at various types of receptors in the plasma membrane. Membrane cholesterol can alter these signaling pathways of living cells. However, the process in...
BMC Biophysics 2016 9:6
Published on: 24 June 2016
Methodology article
The viscoelastic properties of cells have been investigated by a variety of techniques. However, the experimental data reported in literature for viscoelastic moduli differ by up to three orders of magnitude. ...
BMC Biophysics 2016 9:5
Published on: 22 June 2016
Research Article
Knowing the binding site of protein–protein complexes helps understand their function and shows possible regulation sites. The ultimate goal of protein–protein docking is the prediction of the three-dimensiona...
BMC Biophysics 2016 9:4
Published on: 21 April 2016
Reviewer acknowledgement
The editors of BMC Biophysics would like to thank all our reviewers who have contributed to the journal in Volume 8 (2015).
BMC Biophysics 2016 9:3
Published on: 9 February 2016
Research Article
Transcription in Escherichia coli generates positive supercoiling in the DNA, which is relieved by the enzymatic activity of gyrase. Recently published experimental evidence suggests that transcription initiation...
BMC Biophysics 2016 9:2
Published on: 6 February 2016
Research article
The pathological hallmark of Parkinson’s disease is the deposition of cytoplasmic neuronal inclusions termed Lewy bodies. The major component of Lewy bodies is amyloid fibrils of α-synuclein. To investigate wh...
BMC Biophysics 2016 9:1
Published on: 3 February 2016
Research Article
The possibility of validating biological macromolecules with locally disordered domains like RNA against solution properties is helpful to understand their function. In this work, we present a computational sc...
BMC Biophysics 2015 8:11
Published on: 1 December 2015
Research Article
We study the relevance of diffusion for the dynamics of signaling pathways. Mathematical modeling of cellular diffusion leads to a coupled system of differential equations with Robin boundary conditions which ...
BMC Biophysics 2015 8:10
Published on: 14 October 2015
Methodology article
Single-molecule techniques have proven to be an excellent approach for quantitatively studying DNA-protein interactions at the single-molecule level. In magnetic tweezers, a force is applied to a biopolymer th...
BMC Biophysics 2015 8:9
Published on: 25 September 2015
Research Article
The biophysical characteristics of cells determine their shape in isolation and when packed within tissues. Cells can form regular or irregular epithelial structures, round up and form clusters, or deform and ...
BMC Biophysics 2015 8:8
Published on: 12 May 2015
Research Article
The calculation of diffusion-controlled ligand binding rates is important for understanding enzyme mechanisms as well as designing enzyme inhibitors.
BMC Biophysics 2015 8:7
Published on: 7 May 2015
Methodology article
Spin labels, which are chemically stable radicals attached at specific sites of a bio-molecule, enable investigations on structure and dynamics of proteins and nucleic acids using techniques such as site-direc...
BMC Biophysics 2015 8:6
Published on: 9 April 2015
Research article
Time-correlated Förster resonance energy transfer (FRET) probes molecular distances with greater accuracy than intensity-based calculation of FRET efficiency and provides a powerful tool to study biomolecular ...
BMC Biophysics 2015 8:5
Published on: 3 April 2015
Correspondence
The cell contains highly dynamic structures exploiting physical principles of self-organisation at the mesoscale (100 nm to 10 μm). Examples include non-membrane bound cytoplasmic bodies, cytoskeleton-based mo...
BMC Biophysics 2015 8:4
Published on: 25 February 2015
Reviewer Acknowledgement
The editors of BMC Biophysics would like to thank all our reviewers who have contributed to the journal in Volume 7 (2014).
BMC Biophysics 2015 8:3
Published on: 10 February 2015
Research article
Cells exhibit distortion when exposed to a strong electric field, suggesting that the field imposes control over cellular biomechanics. Closed pure lipid bilayer membranes (vesicles) have been widely used for ...
BMC Biophysics 2015 8:2
Published on: 21 January 2015
Research
The recent developments of far-field optical microscopy (single molecule imaging techniques) have overcome the diffraction barrier of light and improve image resolution by a factor of ten compared with convent...
BMC Biophysics 2015 8:1
Published on: 13 January 2015
Methodology article
The ion transport stoichiometry (q) of electrogenic transporters is an important determinant of their function. q can be determined by the reversal potential (Erev) if the transporter under study is the only elec...
BMC Biophysics 2014 7:14
Published on: 11 December 2014
Research article
The polyvalent acidic lipid phosphatidylinositol, 4,5-bisphosphate (PIP2) is important for many cellular functions. It has been suggested that different pools of PIP2 exist in the cytoplasmic leaflet of the plasm...
BMC Biophysics 2014 7:13
Published on: 26 November 2014
