From: Using default constraints of the spindle assembly checkpoint to estimate the associated chemical rates
Parameter
Description
Value
V
cell volume
≈ 100 μm 3 [25]
D
Diffusion coefficient of Cdc20
D = 20 μm2/sec [25]
a
radius of APC/C complex
≈ 10-2 μm [3]
b
radius of MCC binding site
≈ 2nm [37]
N
Number of chromosomes
13 [25]
S
Initial number of complexes
3000 [25]
μ
binding rate = 4 a D V
≈ 2.10-4s-1
