Skip to main content

Table 3 Common ligand binding pockets defined for GPCRs with structural information

From: A minimal ligand binding pocket within a network of correlated mutations identified by multiple sequence and structural analysis of G protein coupled receptors

CXCR4 β2AR β1AR BR SR D3R A2A
M1, G3, L31, Q36, F37, M44, T93, T94, T97, S98, F103, E113, G114, A117, T118, P171, L172, Y178, I179, P180, T193, P194, H195, E196, E197, N200, F203, V204, M207, Y268, A272, I275, H278, Q279, S281, P285, M288, T289, A292 M86, T94, T97, S98, F103, E113, G114, A117, T118, G121, E122, I179, P180, I189, Y191, F203, V204, M207, F208, H211, W265, Y268, A269, A272, P285, M288, T289, A292, F293, K296 T94, T97, S98, E113, G114, A117, T118, G121, E122, I179, P180, I189, Y191, F203, V204, M207, F208, H211, W265, Y268, A269, A272, M288, T289, A292, F293, K296 E113, G114, A117, T118, G121, E122, L125, Y178, E181, S186, C187, G188, I189, Y191, M207, F208, H211, F212, F261, W265, Y268, A269, A272, A292, F293, A295, K296 M86, G90, E113, G114, A117, T118, G121, E122, L125, Y178, E181, S186, C187, G188, I189, M207, F208, H211, F212, F261, W265, Y268, A269, A292, K296 T94, E113, G114, A117, T118, G121, E122, P180, G188, I189, V204, M207, F208, H211, W265, Y268, A269, A272, F273, M288, A292, K296 T118, P180, E181, F203, M207, W265, Y268, A269, A272, F283, P285, M288, T289, A292
39 30 27 27 25 22 14
  1. The residues listed are analogous binding pockets mapped onto the rhodopsin structure (1U19). The binding pockets are arranged in the order of decreasing size of the binding pocket (left to right). The numbers in the last row represent the number of residues in the binding pocket.