Figure 7From: Molecular dynamics simulations indicate an induced-fit mechanism for LSD1/CoREST-H3-histone molecular recognitionLSD1/CoREST local conformational changes upon H3-histone binding are consistent with an induced-fit model. (a) Reference X-ray structure (PDB entry 2V1D). Representative conformations from molecular dynamics (b) unbound and (c) H3-bound conformational ensembles highlight the residues involved in the induced-fit mechanism, as detailed in panels (d-f).Back to article page