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Table 3 Simulation of ΔI and ΔE rev methods to estimate q in conditions similar to rat proximal tubule in the absence or presence of a Na + /D-glucose cotransporter

From: A novel delta current method for transport stoichiometry estimation

[HCO 3 ] o = 24, [HCO 3 ] i = 13.4

V I=0(mV)

ΔE rev(mV)

q (ΔE rev)

ΔI 2/ΔI 1V 2-V 1 = 10 mV

q (ΔI)

[Na +] i = 17 mM

[Na +] o = 150

[Na +] o = 100

q = 2

−89.6

−78.75

10.85

2.0

1.205

2.0

q = 3

−52.6

−47.2

5.4

3.0

1.45

3.0

q = 2, + Glu

−73.6

−62.75

10.85

2.0

1.205

2.0

q = 3, + Glu

3.2

10.2

7.0

2.55

1.45

3.0

  1. Glu represent a Na+/D-glucose cotransporter SGLT2 in the conditions of glucose concentrations [G]o = 5, [G]i = 1 and [Na+]o = 150, [Na+]i = 17 (in mM). Column q (ΔErev) represent q values estimated with ΔErev method. Column q (ΔI) represent q values estimated with ΔI method.