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Fig. 12 | BMC Biophysics

Fig. 12

From: PDE/ODE modeling and simulation to determine the role of diffusion in long-term and -range cellular signaling

Fig. 12

Spatial distribution of IL-2 in the extracellular domain. a 31 (of 125) secreting cells, high IL-2 distribution all over at t=1h, b lowest mean IL-2 distribution, heterogenous pattern, 20 activated cells at t=8h, c heterogenous IL-2 distribution, 33 activated cells in the steady state at t=30h d 31 secreting cells, 31 regulatory T-cells (of 125), low IL-2 distribution after t=1h, e very low IL-2 concentration after t=8h, no cell activated, f very low IL-2 concentration after t=30h, no cell activated. The IL-2 distribution is visualized by isosurfaces obtained from topological methods [22]

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