Fig. 1From: A biophysical model of supercoiling dependent transcription predicts a structural aspect to gene regulationPositive Supercoiling (Pcoil) is produced when mRNA is transcribed. Pcoil inhibits the production of mRNA by reducing the initiation rate. In order to relieve Pcoil gyrase must bind (Gyrase’), which converts Pcoil into the “regular” state (Rcoil)Back to article page