Fig. 2
Structure of hLf with two main lobes (C-terminal left and N-terminal right) and a cleft between domains in each lobe. a) Comparison of closed-open vs. closed-closed structure with the iron ions (red spheres) marking the binding sites. Closed-open is shown in white-black-bordered, closed-closed is color-coded by distance of the Cα-atoms between the structures: from 0 Å (blue) to 32 Å (red). b) The same representation for open-open vs. closed-open structure. c) Shows the translation distances of Cα-atoms between the respective structures. Only about 1/4 of the residues show a large displacement when closing one cleft