Table 2 FoldX predictions of RAS mutation effects for RAS complexes
From: Modeling of RAS complexes supports roles in cancer for less studied partners
| RAS Isoform | Interaction Partner | Mutation | Effect |
|---|---|---|---|
| HRAS | BCL2 | A146T | stabilizing |
| HRAS | FHOD1 | G12D | de-stabilizating |
| HRAS | FHOD1 | G13D | de-stabilizating |
| HRAS | FHOD1 | Q61H | stabilizing |
| HRAS | RALGDS | G12D | stabilizing |
| HRAS | RALGDS | G13D | stabilizing |
| HRAS | RALGDS | A59G | stabilizing |
| KRAS | RALGDS | G13D | stabilizing |