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Table 2 The fitted parameters from the CCL11 and CCL24 folding/unfolding kinetics data

From: Kinetic and thermodynamic studies reveal chemokine homologues CC11 and CC24 with an almost identical tertiary structure have different folding pathways

 

k ff (m ff )a

k fu (m fu )

ΔG fast (m fast eq)a

p-value â–³

k sf (m sf )

k su (m su )

ΔG slow (m slow eq)

p-valueâ–³

CCL11

15.9 Â± 0.6 (0.3 Â± 0.1)

2.7 Â± 0.8 (−0.4 Â± 0.1)

−1.1 Â± 0.1 (0.7 Â± 0.02)

<0.01

2.4 Â± 0.1 (0.4 Â± 0.02)

0.1 Â± 0.02 (−0.5 Â± 0.01)

−2.1 Â± 0.1 (0.9 Â± 0.02)

<0.05

CCL24

17.4 Â± 0.1 (0.2 Â± 0.1)

0.1 Â± 0.02 (−0.5 Â± 0.01)

−2.9 Â± 0.1 (0.7 Â± 0.02)

<0.05

–

–

–

 
  1. aThe units for k, m and ΔG are s−1, kcal mol−1 M−1 and kcal mol−1, respectively. The kinetic parameters (such as k ff , k fu , k sf and k su ) were fitted and averaged at least from three repeats. â–³The p-values were obtained using t-test function of Excel software
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BMC Biophysics

ISSN: 2046-1682

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