Ion |
Cu
2+
|
Ca
2+
|
|---|
Competitor | None |
Ca
2+
| None |
Cu
2+
|
|---|
Δ
H
1
| − 5.7≤−3.4≤−2.8 | − 4.1≤−3.6≤−3.2 | − 1.8≤−1.4≤−0.7 | − 1.5≤−1.2≤−0.7 |
Δ
H
2
| – | – | − 5.7≤−4.6≤−3.7 | − 5.0≤−4.1≤−3.4 |
K
d,1
| 0.9≤1.8≤3.9 | 0.7≤1.0≤1.5 | 0.4≤0.5≤2.7 | 0.03≤0.2≤2.2 |
K
d,2
| – | – | 1.9≤6.3≤34.9 | 1.9≤10.5≤100 |
fx. comp. | 1.40≤1.43≤1.47 | 1.15≤1.17≤1.19 | 0.61≤0.66≤0.69 | 0.54≤0.58≤0.61 |
- Table contains values for key parameters determined via global fits of ITC data using the Bayesian MCMC fitter in pytc. Ninety-five percent credibility regions from the posterior distributions are reported for parameter values. Δ
H values are reported in kcal·mol
−1, K
d
values in μ
M. Final parameter is fraction competent, a nuisance parameter that captures what fraction of the metal and protein in solution are competent for the measured reaction
