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  1. Bacterial sodium channels are important models for understanding ion permeation and selectivity. However, their homotetrameric structure limits their use as models for understanding the more complex eukaryotic...

    Authors: Huaping Sun, Zeyu Zheng, Olena A. Fedorenko and Stephen K. Roberts

    Citation: BMC Biophysics 2019 12:1

    Content type: Research article

    Published on:

  2. Cellular environments are highly crowded with biological macromolecules resulting in frequent non-specific interactions. While the effect of such crowding on protein structure and dynamics has been studied ext...

    Authors: Asli Yildirim, Nathalie Brenner, Robert Sutherland and Michael Feig

    Citation: BMC Biophysics 2018 11:8

    Content type: Research article

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  3. Intracellular phase separation and aggregation of proteins with extended poly-glutamine (polyQ) stretches are hallmarks of various age-associated neurodegenerative diseases. Progress in our understanding of su...

    Authors: Christian V. Hansen, Hans J. Schroll and Daniel Wüstner

    Citation: BMC Biophysics 2018 11:7

    Content type: Methodology article

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  4. With the passing of Jörg Langowski 6 May 2017 in a sailplane accident, the scientific community was deprived of a strident and effective voice for DNA and chromatin molecular and computational biophysics, for ...

    Authors: Giuseppe Chirico, Alexander Gansen, Sanford H. Leuba, Ada L. Olins, Donald E. Olins, Jeremy C. Smith and Katalin Tóth

    Citation: BMC Biophysics 2018 11:5

    Content type: Correspondence

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  5. Astrocytes were conceived for decades only as supporting cells of the brain. However, the observation of Ca2+ waves in astrocyte synctitia, their neurotransmitter receptor expression and gliotransmitter secret...

    Authors: Pavel Montes de Oca Balderas and Horacio Montes de Oca Balderas

    Citation: BMC Biophysics 2018 11:3

    Content type: Research article

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  6. The pathways of thermal instability of amino acids have been unknown. New mass spectrometric data allow unequivocal quantitative identification of the decomposition products.

    Authors: Ingrid M. Weiss, Christina Muth, Robert Drumm and Helmut O. K. Kirchner

    Citation: BMC Biophysics 2018 11:2

    Content type: Research article

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  7. Cell based carriers are increasingly recognized as a good system for cargo delivery to cells. One of the reasons is their biocompatibility and low toxicity compared to artificial systems. Giant plasma membrane...

    Authors: Špela Zemljič Jokhadar, Urška Klančnik, Maja Grundner, Tjaša Švelc Kebe, Saša Vrhovec Hartman, Mirjana Liović and Jure Derganc

    Citation: BMC Biophysics 2018 11:1

    Content type: Research article

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  8. S100A5 is a calcium binding protein found in a small subset of amniote tissues. Little is known about the biological roles of S100A5, but it may be involved in inflammation and olfactory signaling. Previous wo...

    Authors: Lucas C. Wheeler and Michael J. Harms

    Citation: BMC Biophysics 2017 10:8

    Content type: Research article

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  9. Proteins with low sequence identity but almost identical tertiary structure and function have been valuable to uncover the relationship between sequence, tertiary structure, folding mechanism and functions. Tw...

    Authors: Baosheng Ge, Xiaoyong Jiang, Yao Chen, Tingting Sun, Qiuxia Yang and Fang Huang

    Citation: BMC Biophysics 2017 10:7

    Content type: Research article

    Published on:

  10. RAS protein interactions have predominantly been studied in the context of the RAF and PI3kinase oncogenic pathways. Structural modeling and X-ray crystallography have demonstrated that RAS isoforms bind to ca...

    Authors: H. Billur Engin, Daniel Carlin, Dexter Pratt and Hannah Carter

    Citation: BMC Biophysics 2017 10(Suppl 1):5

    Content type: Research

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    This article is part of a Supplement: Volume 10 Supplement 1

  11. The Cry toxins, or δ-endotoxins, are a diverse group of proteins produced by Bacillus thuringiensis. While DNA secondary structures are biologically relevant, it is unknown if such structures are formed in region...

    Authors: Efrain H. Pinzon, Daniel A. Sierra, Miguel O. Suarez, Sergio Orduz and Alvaro M. Florez

    Citation: BMC Biophysics 2017 10:4

    Content type: Research article

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  12. The Biomembrane Force Probe is an approachable experimental technique commonly used for single-molecule force spectroscopy and experiments on biological interfaces. The technique operates in the range of force...

    Authors: Daniel Šmít, Coralie Fouquet, Mohamed Doulazmi, Frédéric Pincet, Alain Trembleau and Martin Zapotocky

    Citation: BMC Biophysics 2017 10:2

    Content type: Software

    Published on:

  13. Human lactoferrin is an iron-binding protein of the innate immune system consisting of two connected lobes, each with a binding site located in a cleft. The clefts in each lobe undergo a hinge movement from op...

    Authors: Clemens Sill, Ralf Biehl, Bernd Hoffmann, Aurel Radulescu, Marie-Sousai Appavou, Bela Farago, Rudolf Merkel and Dieter Richter

    Citation: BMC Biophysics 2016 9:7

    Content type: Research article

    Published on:

  14. The first step in many cellular signaling processes occurs at various types of receptors in the plasma membrane. Membrane cholesterol can alter these signaling pathways of living cells. However, the process in...

    Authors: Chien Y. Lin, Jung Y. Huang and Leu-Wei Lo

    Citation: BMC Biophysics 2016 9:6

    Content type: Research Article

    Published on:

  15. The viscoelastic properties of cells have been investigated by a variety of techniques. However, the experimental data reported in literature for viscoelastic moduli differ by up to three orders of magnitude. ...

    Authors: Yareni A. Ayala, Bruno Pontes, Diney S. Ether, Luis B. Pires, Glauber R. Araujo, Susana Frases, Luciana F. Romão, Marcos Farina, Vivaldo Moura-Neto, Nathan B. Viana and H. Moysés Nussenzveig

    Citation: BMC Biophysics 2016 9:5

    Content type: Methodology article

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  16. The possibility of validating biological macromolecules with locally disordered domains like RNA against solution properties is helpful to understand their function. In this work, we present a computational sc...

    Authors: Aarón Ayllón Benítez, José Ginés Hernández Cifre, Francisco Guillermo Díaz Baños and José García de la Torre

    Citation: BMC Biophysics 2015 8:11

    Content type: Research Article

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  17. The biophysical characteristics of cells determine their shape in isolation and when packed within tissues. Cells can form regular or irregular epithelial structures, round up and form clusters, or deform and ...

    Authors: Ramiro Magno, Verônica A Grieneisen and Athanasius FM Marée

    Citation: BMC Biophysics 2015 8:8

    Content type: Research Article

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  18. Spin labels, which are chemically stable radicals attached at specific sites of a bio-molecule, enable investigations on structure and dynamics of proteins and nucleic acids using techniques such as site-direc...

    Authors: Phuong H Nguyen, Anna M Popova, Kálmán Hideg and Peter Z Qin

    Citation: BMC Biophysics 2015 8:6

    Content type: Methodology article

    Published on:

  19. The cell contains highly dynamic structures exploiting physical principles of self-organisation at the mesoscale (100 nm to 10 μm). Examples include non-membrane bound cytoplasmic bodies, cytoskeleton-based mo...

    Authors: Richard P Sear, Ignacio Pagonabarraga and Andrew Flaus

    Citation: BMC Biophysics 2015 8:4

    Content type: Correspondence

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  20. Cells exhibit distortion when exposed to a strong electric field, suggesting that the field imposes control over cellular biomechanics. Closed pure lipid bilayer membranes (vesicles) have been widely used for ...

    Authors: Hui Ye and Austen Curcuru

    Citation: BMC Biophysics 2015 8:2

    Content type: Research article

    Published on:

  21. The recent developments of far-field optical microscopy (single molecule imaging techniques) have overcome the diffraction barrier of light and improve image resolution by a factor of ten compared with convent...

    Authors: Renmin Han, Liansan Wang, Fan Xu, Yongdeng Zhang, Mingshu Zhang, Zhiyong Liu, Fei Ren and Fa Zhang

    Citation: BMC Biophysics 2015 8:1

    Content type: Research

    Published on:

  22. The polyvalent acidic lipid phosphatidylinositol, 4,5-bisphosphate (PIP2) is important for many cellular functions. It has been suggested that different pools of PIP2 exist in the cytoplasmic leaflet of the plasm...

    Authors: Kyu Il Lee, Wonpil Im and Richard W Pastor

    Citation: BMC Biophysics 2014 7:13

    Content type: Research article

    Published on:

  23. Cells continuously undergo DNA damage from exogenous agents like irradiation or genotoxic chemicals or from endogenous radicals produced by normal cellular metabolic activities. DNA strand breaks are one of th...

    Authors: Michael Junk, Judy Salzwedel, Thilo Sindlinger, Alexander Brkle and Maria Moreno-Villanueva

    Citation: BMC Biophysics 2014 7:9

    Content type: Methodology article

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  24. The complement protein C5a acts by primarily binding and activating the G-protein coupled C5a receptor C5aR (CD88), and is implicated in many inflammatory diseases. The cyclic hexapeptide PMX53 (sequence Ace-P...

    Authors: Phanourios Tamamis, Chris A Kieslich, Gregory V Nikiforovich, Trent M Woodruff, Dimitrios Morikis and Georgios Archontis

    Citation: BMC Biophysics 2014 7:5

    Content type: Research article

    Published on:

  25. A key challenge in interdisciplinary research is choosing the best approach from a large number of techniques derived from different disciplines and their interfaces.

    Authors: Sanford H Leuba, Sean M Carney, Elizabeth M Dahlburg, Rebecca J Eells, Harshad Ghodke, Naveena Yanamala, Grant Schauer and Judith Klein-Seetharaman

    Citation: BMC Biophysics 2014 7:6

    Content type: Correspondence

    Published on:

  26. Based on the dynamics of antigen recognition from T cell receptor complex and T cell activation, different function of T cells may present different morphology feature, at least at molecular level. Regulatory ...

    Authors: Xu Wang, Zhenyi Jin, Xinyu Wang, Shaohua Chen, Lijian Yang, Kanger Zhu, Xiuli Wu and Yangqiu Li

    Citation: BMC Biophysics 2014 7:7

    Content type: Research article

    Published on:

  27. Brownian dynamics (BD) simulations can be used to study very large molecular systems, such as models of the intracellular environment, using atomic-detail structures. Such simulations require strategies to con...

    Authors: Paolo Mereghetti, Michael Martinez and Rebecca C Wade

    Citation: BMC Biophysics 2014 7:4

    Content type: Research article

    Published on:

  28. Viroids are the smallest pathogens of plants. To date the structural and conformational details of the cleavage of Avocado sunblotch viroid (ASBVd) and the catalytic role of Mg2+ ions in efficient self-cleavage a...

    Authors: Gaston Hui-Bon-Hoa, Hussein Kaddour, Jacques Vergne, Sergei G Kruglik and Marie-Christine Maurel

    Citation: BMC Biophysics 2014 7:2

    Content type: Research article

    Published on:

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